文献详情
Models of global gene expression define major domains of cell type and tissue identity
文献类型期刊
作者Hutchins, Andrew P.[1];Yang, Zhongzhou[2];Li, Yuhao[3];He, Fangfang[4];Fu, Xiuling[5];Wang, Xiaoshan[6];Li, Dongwei[7];Liu, Kairong[8];He, Jiangping[9];Wang, Yong[10];Chen, Jiekai[11];Esteban, Miguel A.[12];Pei, Duanqing[13]
机构
通讯作者Hutchins, AP (reprint author), Southern Univ Sci & Technol China, Dept Biol, Shenzhen 518055, Guangdong, Peoples R China.; Hutchins, AP; Pei, DQ (reprint author), Chinese Acad Sci, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China.; Hutchins, AP; Pei, DQ (reprint author), Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Stem Cells & Regenerat Med, Guangzhou 510530, Guangdong, Peoples R China.
来源信息年:2017  卷:45  期:5  页码范围:2354-2367  
期刊信息NUCLEIC ACIDS RESEARCH影响因子和分区  ISSN:0305-1048
增刊正刊
摘要The current classification of cells in an organism is largely based on their anatomic and developmental origin. Cells types and tissues are traditionally classified into those that arise from the three embryonic germ layers, the ectoderm, mesoderm and endoderm, but this model does not take into account the organization of cell type-specific patterns of gene expression. Here, we present computational models for cell type and tissue specification derived from a collection of 921 RNA-sequencing samples from 272 distinct mouse cell types or tissues. In an unbiased fashion, this analysis accurately predicts the three known germ layers. Unexpectedly, this analysis also suggests that in total there are eight major domains of cell type-specification, corresponding to the neurectoderm, neural crest, surface ectoderm, endoderm, mesoderm, blood mesoderm, germ cells and the embryonic domain. Further, we identify putative genes responsible for specifying the domain and the cell type. This model has implications for understanding trans-lineage differentiation for stem cells, developmental cell biology and regenerative medicine.
收录情况SCIE(WOS:000397286600020)  
DOI10.1093/nar/gkx054
百度学术Models of global gene expression define major domains of cell type and tissue identity
语言外文
被引频次33
人气指数972
浏览次数972
基金National Natural Science Foundation of China [31471242, 31550110206, 11422108]; NSFC grants; core Shenzhen funding
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