文献详情
Diffusion tensor imaging of spinal cord parenchyma lesion in rat with chronic spinal cord injury
文献类型期刊
作者Zhao, Can[1];Rao, Jia-Sheng[2];Pei, Xiao-Jiao[3];Lei, Jian-Feng[4];Wang, Zhan-Jing[5];Zhao, Wen[6];Wei, Rui-Han[7];Yang, Zhao-Yang[8];Li, Xiao-Guang[9]
机构
通讯作者Li, XG (reprint author), Beihang Univ, Sch Biol Sci & Med Engn, Beijing Key Lab Biomat & Neural Regenerat, 37 Xueyuan Rd, Beijing 100191, Peoples R China.
来源信息年:2018  卷:47  页码范围:25-32  
期刊信息MAGNETIC RESONANCE IMAGING影响因子和分区  ISSN:0730-725X
关键词Chronic spinal cord injury; Diffusion tensor imaging; Fiber tractography; Cavity
增刊正刊
摘要Purpose: Adequate evaluation of spinal cord parenchyma and accurate identification of injury range are considered two premises for the research and treatment of chronic spinal cord injury (SCI). Diffusion tensor imaging (DTI) provides information about water diffusion in spinal cord, and thus makes it possible to realize these premises. Method: In this study, we conducted magnetic resonance imaging (MRI) for Wistar rats 84 days after spinal cord contusion. DTI metrics including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) from different positions of the injured cord were collected, analyzed, and compared with the histological results and locomotor outcomes. Moreover, we performed fiber tractography, and examined the difference in cavity percentage obtained respectively via conventional MRI, DTI and histology. Results: Results showed that the chronic SCI rats had the largest changes of all DTI metrics at the epicenter; the farther away from the epicenter, the smaller the variation. FA, AD and RD were all influenced by SCI in a greater space range than MD. The good consistency of FA values and histological results in specific regions evidenced FA's capability of reflecting Wallerian degeneration after SCI. DTI metrics at the epicenter in ventral funiculus also showed a close correlation with the BBB scores. Additionally, supported by the histological results, DTI enables a more accurate measurement of cavity percentage compared to the conventional MRI. Conclusion: DTI parameters might comprehensively reflect the post-SCI pathological status of spinal cord parenchyma at the epicenter and distal parts during the chronic stage, while showing good consistency with locomotor performance. DTI combined with tractography could intuitively display the distribution of spared fibers after SCI and accurately provide information such as cavity area. This may shed light on the research and treatment of chronic SCI.
收录情况SCIE(WOS:000428004500004)  PubMed(29154896)  
所属部门生物与医学工程学院
链接地址https://www.scopus.com/inward/record.uri?eid=2-s2.0-85034424979&doi=10.1016%2fj.mri.2017.11.009&partnerID=40&md5=a01b454dca9650aaff2722ee75543ff6
DOI10.1016/j.mri.2017.11.009
百度学术Diffusion tensor imaging of spinal cord parenchyma lesion in rat with chronic spinal cord injury
语言外文
人气指数99
浏览次数98
基金National Key RD Plan of China [2017YFC1104001]; Special Funds for Beijing Base Construction & Talent Cultivation [Z171100002217066]; Beihang University [ZG216S17C8]; International Science & Technology Cooperation Program of China [2014DFA30640]; National Natural Science Foundation of China [31730030, 31320103903, 31670988]; 111 Project [B13003]
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