文献详情
The modulation effect of the convexity of silicon topological nanostructures on the growth of mesenchymal stem cells
文献类型期刊
作者Zou, Yang[1];Feng, Hongqing[2];Ouyang, Han[3];Jin, Yiming[4];Yu, Min[5];Liu, Zhuo[6];Li, Zhou[7]
机构
通讯作者Li, Z (reprint author), Chinese Acad Sci, Natl Ctr Nanosci & Technol NCNST, Beijing Inst Nanoenergy & Nanosyst, Beijing 100083, Peoples R China.
来源信息年:2017  卷:7  期:28  页码范围:16977-16983  
期刊信息RSC ADVANCES影响因子和分区  ISSN:2046-2069
摘要A series of different topological nanostructures are fabricated on silicon wafer using metal-assisted chemical etching. The modulation effect of these nanostructures on the size, filopodia generation and growth orientation of the rat mesenchymal stem cells (MSCs) are studied. These topological nanostructures tend to induce the MSCs to have smaller size, but they generate much more filopodia compared to the flat silicon control. The modulation effects of these nanostructures are dependent on their surface convexity, as analysed by grey-level value histogram and fast Fourier transformation (FFT). A surface with a higher portion of convex area is better at supporting larger cell sizes. The wavenumber analysis by FFT further determines its effect on filopodia generation. In addition, the growth orientation of the cells are also guided by the surface convexity. On the porous and spongy surface, the cell filopodia extend and grow in avoidance of large sinking pits. On the columnar and spiny surface, the cell body and filopodia extend only on the tips of these nanostructures. Our study reveals that surface convexity is an important factor modulating cell behavior, and convexity analysis by image processing can work as a fast and simple evaluation standard to design topological nanostructures.
收录情况SCIE(WOS:000398802000008)  EI(20171303499499)  
所属部门生物与医学工程学院
DOI10.1039/c7ra00542c
学科化学综合
人气指数89
浏览次数89
基金national key R & D project from Minister of Science and Technology, China [2016YFA0202703]; NSFC [31571006, 81601629]; Beijing Talents Fund [2015000021223ZK21]; "Thousands Talents" program for pioneer researcher and his innovation team
全部评论(0 条评论)
作者其他论文

In Vivo Powering of Pacemaker by Breathing-Driven Implanted Triboelectric Nanogenerator.

Zheng, Qiang;Shi, Bojing;Fan, Fengru,等.ADVANCED MATERIALS.2014,26(33),5851-5856.

An integrated resource allocation algorithm for CPU intensive and I/O intensive jobs in multi-core cluster.

Liang, Aihua;Liu, Zhuo;Xiao, Limin,等.2010 2nd International Conference on Future Computer and Communication, ICFCC 2010.2010,3,V3591-V3594.

Improvement the Teaching of Biochemistry to Meet the Mission of the Knowledge Innovation Era.

Song, Yiling;Song, Wei;Li, Zhou,等.International Conference on Education Science and Management Engineering (ESME).2011,1023-1025.

登录