文献详情
Full-angle fluorescence diffuse optical tomography with spatially coded parallel excitation
文献类型期刊
作者Wang, Daifa[1];Liu, Xin[2];Liu, Fei[3];Bai, Jing[4]
机构
通讯作者Bai, J.(deabj@tsinghua.edu.cn)
来源信息年:2010  卷:14  期:6  页码范围:1346-1354  
期刊信息IEEE Transactions on Information Technology in Biomedicine  ISSN:10897771
增刊正刊
摘要Challenges remain in imaging fast biological activities through whole small animal using fluorescence diffuse optical tomography (FDOT). In this study, a novel full-angle FDOT with spatially coded parallel excitation (SC-FDOT) is proposed, which provides much better image qualities than our previous FDOT with multiple-points illumination (MP-FDOT) while maintaining comparable temporal resolution. Singular-value analysis and numerical simulations are used to obtain the key experimental parameters including the optimal point sources number and the optimal projections number, and to compare the performances of SC-FDOT, MP-FDOT and the conventional FDOT with single-point illumination. Results demonstrate that SC-FDOT has the best spatial-temporal performances in imaging fast biological activities through whole body. Physical phantom experiments are performed to evaluate the spatial performance of SC-FDOT in practical experimental applications. Utilizing the proposed system, a nude mouse implanted with a small fluorescent inclusion is also imaged. The preliminary result demonstrates the feasibility of SC-FDOT in invivo applications. ? 2006 IEEE.
收录情况EI(20104613396786)  
所属部门生物与医学工程学院
DOI10.1109/TITB.2010.2077306
百度学术Full-angle fluorescence diffuse optical tomography with spatially coded parallel excitation
语言外文
人气指数36
浏览次数36
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