文献详情
Neuroimaging endophenotypes of type 2 diabetes mellitus: a discordant sibling pair study
文献类型期刊
作者Zhang, Dong[1];Shi, Lin[2];Song, Xiubao[3];Shi, Changzheng[4];Sun, Pan[5];Lou, Wutao[6];Wang, Defeng[7];Luo, Liangping[8]
机构
通讯作者Luo, LP (reprint author), Jinan Univ, Affiliated Hosp 1, Dept Med, Imaging Ctr, Guangzhou 510630, Guangdong, Peoples R China.; Wang, DF (reprint author), Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100091, Peoples R China.
2019
期刊名称QUANTITATIVE IMAGING IN MEDICINE AND SURGERY影响因子和分区
来源信息年:2019  卷:9  期:6  页码范围:1000-1013  
9
期刊信息QUANTITATIVE IMAGING IN MEDICINE AND SURGERY影响因子和分区  ISSN:2223-4292
6
关键词Neuroimaging; type 2 diabetes mellitus (T2DM); endophenotypes; voxel-based morphometry (VBM); perfusion
页码范围1000-1013
增刊正刊
摘要Background: Type 2 diabetes mellitus (T2DM) is characterized by notable familial aggregation involving common variants of many genes, and its heritability leads to a high prevalence in the siblings of affected individuals compared with the general population. Endophenotypes are objective, heritable, quantitative traits that appear to reflect the genetic risk for polygenic disorders at more biologically tractable levels. Based on a sibling pair design, we aimed to find the neuroimaging endophenotypes of T2DM and investigate the role of inherent neurological disorders in the pathogenesis and deterioration of T2DM. Methods: Twenty-six pairs of diagnosed T2DM patients with unaffected siblings and 26 unrelated controls were included in this study. Both high-resolution structural MRI and three-dimensional pseudo-continuous arterial spin labelling (3D-pCASL) MRI data were acquired with a 3.0 T MRI system. Voxel-based morphometry (VBM) analysis was performed on the structural T1W images, and cerebral blood flow (CBF) maps were obtained. All data were processed with the SPM8 package under the MATLAB 7.6 operation environment. Results: The T2DM patients and their unaffected siblings shared significant atrophy in the right inferior/ middle temporal gyrus, and left insula, in addition to elevated CBF in the right prefrontal lobe. Several regions with abnormal CBF in siblings, including the right inferior/middle temporal gyrus, left insula, left operculum, right supramarginal gyrus, right prefrontal lobe, and bilateral anterior cingulate cortex, also presented significant atrophy in T2DM patients. Conclusions: The shared brain regions with grey matter (GM) loss and CBF increases may serve as neuroimaging endophenotypes of T2DM, and the regions with abnormal CBF in siblings indicate an increased risk for T2DM.
收录情况SCIE(WOS:000473295800009)  
所属部门仪器科学与光电工程学院
DOI10.21037/qims.2019.05.18
百度学术Neuroimaging endophenotypes of type 2 diabetes mellitus: a discordant sibling pair study
语言外文
ISSN2223-4292
人气指数113
浏览次数113
基金Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation [201905010003]; Engineering Research Center of Medical Imaging Artificial Intelligence for Precision Diagnosis and Treatment, Guangdong Province; Collaborative Innovation Program of Hong Kong and Guangdong Province; Guangdong Science and Technique Department [2016A050503032]; Guangzhou External Science and Technology Cooperation Program [201807010046]; Shenzhen Science and Technology Innovation Committee [CYZZ20160421160735632]; Research Grants Council of the Hong Kong Special Administrative Region, China [CUHK 14113214, CUHK 14204117]; Scheme Double First Class Program, Ministry of Education; Ministry of Finance; National Development and Reform Commission; [GHP-025-17SZ]; [GHP-028-14SZ]
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