文献详情
Finding splitting lines for touching cell nuclei with a shortest path algorithm
文献类型期刊
作者Bai, Xiangzhi[1];Wang, Peng[2];Sun, Changming[3];Zhang, Yu[4];Zhou, Fugen[5];Meng, Cai[6]
机构
通讯作者Bai, XZ (reprint author), Beijing Univ Aeronaut & Astronaut, Image Proc Ctr, Beijing 100191, Peoples R China.
来源信息年:2015  卷:63  页码范围:277-286  
期刊信息COMPUTERS IN BIOLOGY AND MEDICINE影响因子和分区  ISSN:0010-4825
关键词Splitting line; Touching cell nuclei; Shortest path; Segmentation
增刊正刊
摘要A shortest path-based algorithm is proposed in this paper to find splitting lines for touching cell nuclei. First, an initial splitting line is obtained through the distance transform of a marker image and the watershed algorithm. The initial splitting line is then separated into different line segments as necessary, and the endpoint positions of these line segments are adjusted to the concave points on the contour. Finally, a shortest path algorithm is used to find the accurate splitting line between the starting-point and the end-point, and the final split can be achieved by the contour of the touching cell nuclei and the splitting lines. Comparisons of experimental results show that the proposed algorithm is effective for segmentation of different types of touching cell nuclei. (C) 2014 Elsevier Ltd. All rights reserved.
收录情况SCIE(WOS:000358269300031)  EI(20144700222372)  PubMed(25458811)  
所属部门宇航学院
DOI10.1016/j.compbiomed.2014.10.008
学科生物学;计算机:跨学科应用;工程:生物医学;数学与计算生物学
百度学术Finding splitting lines for touching cell nuclei with a shortest path algorithm
语言外文
被引频次2
人气指数116
浏览次数116
基金National Natural Science Foundation of China [61271023]; Fundamental Research Funds for the Central Universities [YWF-14-YHXY-029]; 863 Program [2012AA02A606]; Beijing Key Laboratory of Digital Media, Beihang University
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